Description

Gastrin Releasing Peptide (20-27), n-Acetyl-Leu(26)-Psi(Ch2O)Leu(27)- is a potent and selective synthetic peptide antagonist of the gastrin-releasing peptide receptor (GRPR). This compound is of significant value for biochemical and pharmacological research, particularly in studying receptor-ligand interactions and signal transduction pathways. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neurobiology, oncology, and gastrointestinal research.

Application

• Biomedical Research: Used as a critical tool compound for investigating the role of GRP and its receptor in various physiological and pathological processes.
• Signal Transduction Studies: Employed to block GRPR activity, allowing researchers to elucidate downstream signaling cascades in cell-based assays.
• Oncology Research: Applied in studies exploring the involvement of GRPR in cancer cell proliferation, particularly in prostate, lung, and pancreatic cancers.
• Neuropharmacology: Utilized in central nervous system research to understand the neuromodulatory functions of bombesin-like peptides.
• Drug Discovery: Serves as a reference standard and a starting point for the development of novel therapeutic agents targeting the GRPR.
• In Vitro Diagnostics (IVD) Development: Can be used in the development of assay kits for research purposes to detect or quantify GRP/GRPR interactions.

Basic Information

Product Name	Gastrin Releasing Peptide (20-27), n-Acetyl-Leu(26)-Psi(Ch2O)Leu(27)-
CAS No.	125185-94-6
Molecular Formula	C44H72N12O11
Molecular Weight	921.1 g/mol
Synonyms	Acetyl-Leu26-[ψ(CH2O)]Leu27-GRP(20-27); GRP(20-27) Antagonist; [ψ13,14(CH2O)]-Ac-GRP(20-27); Bombesin Receptor Antagonist; GRP Receptor Antagonist; Leu26-ψ13,14(CH2O)-Leu27-GRP(20-27) Amide; n-Acetyl-GRP(20-27) Pseudopeptide
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of Gastrin Releasing Peptide (20-27), n-Acetyl-Leu(26)-Psi(Ch2O)Leu(27)- undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing purity, content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.