Description

12-((-5-Iodo-4-Azido-2-Hydroxybenzoyl)Amino)Dodecanoic Acid Cholesteryl Ester is a sophisticated bifunctional chemical probe designed for advanced biochemical research and labeling applications. This compound matters for its unique structure, which combines a photoreactive azido group, a radioiodinatable site, and a cholesterol moiety for membrane targeting, enabling precise cross-linking and detection studies. It is primarily needed by research institutions and pharmaceutical companies engaged in lipidomics, membrane protein research, and the development of novel diagnostic or therapeutic agents.

Application

• Photoaffinity Labeling Probe: Used in biochemical research to covalently tag and study lipid-binding proteins, receptors, or enzymes upon UV light activation.
• Membrane Biology Studies: The cholesteryl ester tail facilitates incorporation into lipid bilayers and liposomes for investigating membrane dynamics, raft formation, and protein-lipid interactions.
• Radiolabeling Precursor: Serves as a precursor for iodine-125 (125I) labeling, creating radioactive tracers for autoradiography, binding assays, and biodistribution studies.
• Click Chemistry Substrate: The azide group allows for subsequent bioorthogonal "click" reactions with alkynes, enabling fluorescent tagging, pull-down assays, or surface immobilization.
• Lipidomics Research: Employed as a synthetic standard or a derivatization agent in mass spectrometry-based lipid analysis to identify and quantify complex lipid species.
• Drug Delivery System Development: Investigated for the functionalization of nanoparticles or liposomes to create targeted delivery systems with traceable labels.

Basic Information

Product Name	12-((-5-Iodo-4-Azido-2-Hydroxybenzoyl)Amino)Dodecanoic Acid Cholesteryl Ester
CAS No.	125108-88-5
Molecular Formula	C46H69IN4O4
Molecular Weight	893.98 g/mol
Synonyms	Cholesteryl 12-((5-iodo-4-azido-2-hydroxybenzoyl)amino)dodecanoate; N-[12-(Cholesteryloxy)-12-oxododecyl]-5-iodo-4-azido-2-hydroxybenzamide; 5-Iodo-4-azidosalicylamidododecanoic Acid Cholesteryl Ester; Photoactivatable Cholesterol Derivative; Bifunctional Cholesterol Probe; Azido-Iodo Cholesterol Ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (by HPLC), identity confirmation (by NMR and MS), and functional group integrity. We adhere to strict analytical protocols to guarantee batch-to-batch consistency for research reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	< 1.0%
Solubility	Soluble in DMSO, DMF, THF, Chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.