Description

Cyclic Amp-Regulated Phosphoprotein Arpp-21 CAS NO 125004-22-0 is a specialized phosphoprotein that plays a critical role in intracellular signaling pathways regulated by cyclic adenosine monophosphate (cAMP). This compound is essential for researchers and developers studying signal transduction mechanisms, neuronal function, and protein phosphorylation dynamics. It is primarily utilized in biochemical research, pharmaceutical development for neurological disorders, and as a key reagent in proteomics and cell biology studies.

Application

• Biochemical Research: Used as a critical reagent in studies of cAMP-dependent protein kinase (PKA) signaling cascades and phosphoprotein analysis.
• Neuroscience & Neuropharmacology: Employed in research targeting dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) related pathways for potential therapeutic interventions.
• Proteomics & Cell Signaling: Serves as a standard or substrate in assays designed to investigate protein phosphorylation, dephosphorylation, and intracellular communication networks.
• Pharmaceutical Development: Acts as a tool compound for screening and validating drug candidates aimed at modulating phosphoprotein-related targets in neurological and psychiatric conditions.
• Diagnostic Assay Development: Utilized in the development of immunoassays or enzymatic tests to detect and quantify specific phosphoprotein activity.
• Academic Research: Fundamental tool for university and institutional labs exploring the molecular basis of cellular regulation and signal transduction.

Basic Information

Product Name	Cyclic Amp-Regulated Phosphoprotein Arpp-21
CAS No.	125004-22-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ARPP-21; cAMP-regulated phosphoprotein ARPP-21; Dopamine- and cAMP-regulated neuronal phosphoprotein 21; DARPP-21; ARPP21 Protein; Cyclic AMP-regulated phosphoprotein 21; Neuronal phosphoprotein ARPP-21
EINECS	Contact for details

Quality Control

Our Cyclic Amp-Regulated Phosphoprotein Arpp-21 is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including purity assessment by HPLC and identity confirmation. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture. For short-term use, aliquoting is recommended to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Protein Content (Biuret)	≥ 90%
Solubility	Soluble in aqueous buffers
Endotoxin Level	< 1.0 EU/mg
Biological Activity	Assayed by phosphorylation assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.