Description

(R)-3'-Hydroxy Warfarin is a specific stereoisomer of a key warfarin metabolite, distinguished by its precise (R)-configuration at the chiral center and hydroxylation at the 3' position. This compound matters as a critical reference standard and intermediate for pharmaceutical research, enabling the study of warfarin metabolism, pharmacokinetics, and the development of analytical methods. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in anticoagulant drug development, bioanalytical studies, and metabolic pathway investigation.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantification and identification of warfarin metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Metabolic Pathway Research: Serves as a crucial tool for in vitro and in vivo studies to elucidate the stereoselective metabolism of warfarin, investigating enzymes like CYP450 isoforms.
• Analytical Method Development: Employed in the development, validation, and calibration of chromatographic assays for clinical pharmacology and therapeutic drug monitoring.
• Impurity Profiling: Acts as a known impurity or degradation product standard in the quality control of warfarin active pharmaceutical ingredient (API) and finished dosage forms.
• Biochemical Research: Utilized in studies exploring the structure-activity relationships (SAR) of vitamin K antagonists and their interaction with target proteins.
• Toxicology Studies: Applied in research assessing the toxicity and disposition of specific warfarin metabolites.

Basic Information

Product Name	(R)-3'-Hydroxy Warfarin
CAS No.	124997-75-7
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	(R)-3'-Hydroxywarfarin; (3'R)-Hydroxywarfarin; 4-Hydroxy-3-(3-oxo-1-(R)-phenylbutyl)-2H-1-benzopyran-2-one; 3'-OH-Warfarin (R-isomer); Warfarin, 3'-hydroxy-, (R)-; (R)-3-Hydroxywarfarin (common numbering variance); 3'-Hydroxycoumarin derivative
EINECS	Contact for details

Quality Control

Our (R)-3'-Hydroxy Warfarin is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chromatographic data is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.