Description

3-Hydroxy-5-Methoxybenzonitrile is a versatile aromatic nitrile derivative that serves as a critical building block in advanced organic synthesis. Its unique bifunctional structure, featuring both a phenolic hydroxyl and a methoxy group ortho to a nitrile, makes it a valuable intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators, leveraging its phenolic and nitrile functionalities.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials due to its rigid, aromatic core.
• Chemical Biology Probes: Utilized as a scaffold for developing fluorescent tags and molecular probes for biochemical assays and diagnostic applications.

Basic Information

Product Name	3-Hydroxy-5-Methoxybenzonitrile
CAS No.	124993-53-9
Molecular Formula	C8H7NO2
Molecular Weight	149.15 g/mol
Synonyms	5-Methoxy-3-hydroxybenzonitrile; 3-Cyano-5-methoxyphenol; 5-Methoxy-3-hydroxybenzenecarbonitrile; 3-Hydroxy-5-methoxybenzenenitrile; Benzonitrile, 3-hydroxy-5-methoxy-; 3-Hydroxy-5-methoxy-phenyl cyanide
EINECS	Contact for details

Quality Control

Our production of 3-Hydroxy-5-Methoxybenzonitrile adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and Good Manufacturing Practice (GMP) principles where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.