Description

1-Chloro-3-Ethynyl-2,4-Dimethoxybenzene is a high-purity, functionalized aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both an ethynyl group and chlorine and methoxy substituents, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting novel small molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its aromatic core provides a scaffold for bioactive compounds.
• Material Science Research: Serves as a precursor for novel polymers, ligands, or organic electronic materials due to its reactive ethynyl functionality.
• Cross-Coupling Reactions: The chlorine and ethynyl groups make it a suitable substrate for Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Can be used to create tagged molecules or building blocks for click chemistry applications in probe and diagnostic development.

Basic Information

Product Name	1-Chloro-3-Ethynyl-2,4-Dimethoxybenzene
CAS No.	124979-30-2
Molecular Formula	C10H9ClO2
Molecular Weight	196.63 g/mol
Synonyms	3-Chloro-6-ethynyl-1,2-dimethoxybenzene; 2,4-Dimethoxy-1-chloro-3-ethynylbenzene; 1-Chloro-3-ethynyl-2,4-dimethoxy-benzene; Benzene, 1-chloro-3-ethynyl-2,4-dimethoxy-; 124979-30-2; 3-Ethynyl-2,4-dimethoxychlorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-Ethynyl-2,4-Dimethoxybenzene is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, and NMR, to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.