Description

S-4-(3-Pyrrolidinyloxy)-Benzonitrile is a chiral, high-purity organic intermediate featuring a benzonitrile core substituted with a pyrrolidinyloxy moiety. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical agents, particularly those targeting the central nervous system. It is needed by research institutions and pharmaceutical manufacturers engaged in developing new therapeutic molecules, where its specific stereochemistry and functional groups are essential for creating potent and selective active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex molecules where the S-enantiomer configuration is required for biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in reactions requiring enantioselective control to produce single-isomer final compounds.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	S-4-(3-Pyrrolidinyloxy)-Benzonitrile
CAS No.	124817-92-1
Molecular Formula	C11H12N2O
Molecular Weight	188.23 g/mol
Synonyms	(S)-4-(3-Pyrrolidinyloxy)Benzonitrile; (S)-4-(Pyrrolidin-3-yloxy)benzonitrile; S-4-(3-Pyrrolidinyloxy)Benzonitrile; Benzonitrile, 4-[(3S)-3-pyrrolidinyloxy]-; (3S)-4-(4-Cyanophenoxy)-3-pyrrolidine; (S)-4-(3-Pyrrolidinoloxy)benzonitrile
EINECS	Contact for details

Quality Control

Our S-4-(3-Pyrrolidinyloxy)-Benzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and identity verification. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.