Description

Heat Shock Protein, 65 Kd, Mycobacterium Bovis Bcg, Fragment 180-188 is a defined synthetic peptide fragment derived from the 65 kDa heat shock protein (HSP65) of Mycobacterium bovis BCG. This immunologically active sequence is critical for research into cellular immune responses, particularly in the context of autoimmune diseases, tuberculosis, and vaccine development. It is an essential reagent for immunologists and pharmaceutical researchers focused on T-cell epitope mapping, antigen-specific immune modulation, and diagnostic assay development.

Application

• Immunological Research: Used as a specific antigen to study T-cell mediated immune responses, including the activation and proliferation of CD4+ and CD8+ T cells.
• Autoimmune Disease Studies: Serves as a key epitope in research models for conditions like rheumatoid arthritis, where HSP65 is implicated in pathogenesis.
• Vaccine Development: Employed in the design and evaluation of novel peptide-based vaccines against tuberculosis and other mycobacterial infections.
• Diagnostic Reagent: Utilized in the development of in vitro assays (e.g., ELISpot, intracellular cytokine staining) to detect antigen-specific T-cell responses in clinical samples.
• Epitope Mapping: A standard tool for defining and validating major histocompatibility complex (MHC) binding motifs and T-cell receptor interactions.
• Quality Control Standard: Acts as a reference standard in the production and quality assurance of related immunological reagents and diagnostic kits.

Basic Information

Product Name	Heat Shock Protein, 65 Kd, Mycobacterium Bovis Bcg, Fragment 180-188
CAS No.	124774-36-3
Molecular Formula	C46H78N14O13
Molecular Weight	1027.2 g/mol
Synonyms	HSP65 (180-188); BCG HSP65 Peptide (180-188); Mycobacterium bovis HSP65 Fragment 180-188; Antigenic Peptide p180-188; T-cell Epitope HSP65180-188; Mycobacterial Heat Shock Protein 65 Peptide; Peptide Fragment (180-188) of 65 kDa Heat Shock Protein
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under stringent quality systems. Each batch of Heat Shock Protein, 65 Kd, Mycobacterium Bovis Bcg, Fragment 180-188 is subjected to comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and amino acid analysis. We support research and development requiring high-purity, well-characterized biological reagents.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For optimal performance, prepare aliquots to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute aqueous acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.