Description

Tyr-α-Cgrp (Human) is a synthetic peptide fragment corresponding to a specific region of the human Calcitonin Gene-Related Peptide (CGRP). This high-purity biochemical is critical for advanced research and development in neuroscience and cardiovascular pharmacology. It serves as a key reference standard and active pharmaceutical ingredient (API) intermediate for scientists and manufacturers developing targeted therapeutic agents. Its primary utility is in binding studies, assay development, and the production of diagnostic and therapeutic compounds targeting CGRP pathways.

Application

• Pharmaceutical R&D: Used as a reference standard and building block in the development of novel CGRP receptor antagonists for migraine and cardiovascular therapies.
• Biochemical Research: Essential for in vitro binding assays, receptor characterization, and signal transduction studies related to the CGRP system.
• Diagnostic Development: Serves as a critical antigen or calibrator in the development of immunoassays (ELISA, RIA) for detecting CGRP levels in biological samples.
• Neuroscience Studies: Applied in research investigating the role of CGRP in pain transmission, neurogenic inflammation, and vascular regulation.
• Peptide Synthesis: Acts as a key intermediate or fragment for the solid-phase or solution-phase synthesis of larger, modified CGRP analogs.
• Quality Control: Employed as a system suitability standard in analytical laboratories to validate methods for peptide-based drug purity and potency.

Basic Information

Product Name	Tyr-α-Cgrp (Human)
CAS No.	124756-98-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Tyr-CGRP (Human); Tyrosylated α-Calcitonin Gene-Related Peptide (Human); α-CGRP (Human), Tyr-modified; Calcitonin Gene-Related Peptide Fragment (Human); CGRP (8-37), Human, Tyr-analog; H-Tyr-CGRP; CGRP receptor ligand; CGRP antagonist precursor
EINECS	Contact for details

Quality Control

Every batch of Tyr-α-Cgrp (Human) is manufactured under controlled conditions and subjected to rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates. Standard testing includes HPLC for purity, MS for identity confirmation, and amino acid analysis. Comprehensive Certificates of Analysis (COA) detailing all test results and specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.