Description

S-(Bismaleimidoethyl Ether)Cysteine is a heterobifunctional crosslinking agent featuring a maleimide group and a thiol-reactive cysteine moiety. This compound is engineered for the site-specific conjugation of biomolecules, enabling the creation of stable thioether bonds under mild conditions. It is an essential reagent for researchers and manufacturers in bioconjugation, particularly for developing antibody-drug conjugates (ADCs), protein-protein conjugates, and advanced diagnostic probes.

Application

• Bioconjugation Reagent: Primary tool for linking peptides, proteins, or antibodies to other molecules like drugs, fluorophores, or polymers.
• Antibody-Drug Conjugate (ADC) Development: Enables the precise attachment of cytotoxic payloads to monoclonal antibodies via a stable linker.
• Protein Labeling & Immobilization: Used for site-specific fluorescent or enzymatic labeling of proteins for assays and diagnostics.
• Polymer & Biomaterial Modification: Functionalizes surfaces or hydrogel matrices with bioactive peptides to control cell-material interactions.
• Diagnostic Probe Synthesis: Facilitates the construction of targeted imaging agents for in vitro and in vivo diagnostics.
• Peptide & Small Molecule Conjugation: Creates novel peptide-drug or peptide-polymer hybrids for therapeutic and research applications.

Basic Information

Product Name	S-(Bismaleimidoethyl Ether)Cysteine
CAS No.	124505-88-0
Molecular Formula	C13H17N3O5S
Molecular Weight	327.36 g/mol
Synonyms	N-(2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethyl)-L-cysteine; S-[2-[2-(2,5-Dioxo-2H-pyrrol-1-yl)ethoxy]ethyl]cysteine; BMEE-Cysteine; Maleimide-PEG2-Cysteine; 1-[2-[2-(2-Sulfanylethoxy)ethoxy]ethyl]-1H-pyrrole-2,5-dione; Heterobifunctional PEG Crosslinker; Cysteine Maleimide Crosslinker
EINECS	Contact for details

Quality Control

Our S-(Bismaleimidoethyl Ether)Cysteine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing consistent performance and traceability for your critical bioconjugation workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.