Description

(Tyr27)-α-Cgrp (27-37) (Rat) is a synthetic peptide fragment corresponding to the C-terminal region of rat α-Calcitonin Gene-Related Peptide (α-CGRP). This compound is a critical research-grade biochemical tool used to study the structure-activity relationships and receptor binding mechanisms of CGRP, a potent neuropeptide involved in vasodilation and pain signaling. It is essential for researchers in neuroscience, cardiovascular pharmacology, and drug discovery who require high-purity, well-characterized peptide analogs for in vitro and in vivo studies.

Application

• Neuroscience Research: Investigation of CGRP receptor subtypes (CGRP1 and CGRP2) and their signaling pathways in the central and peripheral nervous systems.
• Pharmacological Studies: Used as a reference standard or competitive ligand in receptor binding assays and functional bioassays to evaluate novel CGRP antagonists.
• Cardiovascular Research: Study of CGRP's role in vascular tone regulation, migraine pathophysiology, and inflammatory responses.
• Structure-Activity Relationship (SAR) Analysis: Serves as a key analog for mapping the bioactive epitopes of the full-length α-CGRP peptide.
• Biochemical Reagent: Utilized in the development and validation of immunoassays (e.g., ELISA, RIA) for CGRP detection and quantification.
• Academic & Institutional Research: A fundamental tool for universities and research institutes focusing on neuropeptide biology and peptide therapeutics.

Basic Information

Product Name	(Tyr27)-α-Cgrp (27-37) (Rat)
CAS No.	124501-79-7
Molecular Formula	C66H101N19O19
Molecular Weight	1464.6 g/mol
Synonyms	Tyr27-α-CGRP (27-37), rat; α-Calcitonin Gene-Related Peptide (27-37) [Tyr27] analog; CGRP (27-37), [Tyr27]-; H-Val-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Tyr-NH2; CGRP fragment 27-37 (rat, Tyr27); Calcitonin gene-related peptide 1 (27-37), [Tyr27]-; [Tyr27]rαCGRP(27-37)
EINECS	Contact for details

Quality Control

Every batch of (Tyr27)-α-Cgrp (27-37) (Rat) is manufactured and analyzed under strict quality protocols to ensure identity, purity, and consistency suitable for advanced research applications. Our quality assurance includes comprehensive analytical testing via HPLC for purity and MS for identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay purity, peptide content, and solvent residues.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.