Description

Z-D-Tyrosine Methyl Ester 97% (98% Ee) is a high-purity, non-natural amino acid derivative featuring a D-configuration at the alpha carbon and a Z-protecting group on the amine. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, where stereochemical control is paramount. It is primarily utilized by pharmaceutical research and development teams, as well as by fine chemical manufacturers specializing in active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs and protease inhibitors.
• Peptide Chemistry Research: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce D-tyrosine residues with orthogonal protection.
• Bioconjugation & Probe Development: Serves as a precursor for fluorescent or affinity tags in biochemical assay development.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in the preparation of enantiomerically pure compounds.
• Academic & Industrial R&D: Fundamental research tool in medicinal chemistry and chemical biology for structure-activity relationship (SAR) studies.

Basic Information

Product Name	Z-D-Tyrosine Methyl Ester 97% (98% Ee)
CAS No.	124456-04-8
Molecular Formula	C19H21NO5
Molecular Weight	343.38 g/mol
Synonyms	N-Carbobenzoxy-D-tyrosine methyl ester; Z-D-Tyr-OMe; (R)-Methyl 2-((((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanoate; Benzyl N-[(1R)-1-(4-hydroxyphenyl)-2-methoxy-2-oxoethyl]carbamate; D-Tyrosine, N-[(phenylmethoxy)carbonyl]-, methyl ester; Methyl N-carbobenzoxy-D-tyrosinate; Z-D-Tyrosine O-methyl ester
EINECS	Contact for details

Quality Control

Our Z-D-Tyrosine Methyl Ester is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for assay and enantiomeric excess (Ee) determination, and spectroscopic methods (NMR, IR) for structural confirmation. We provide Certificates of Analysis (COA) with each shipment, detailing purity, chiral purity, and impurity profiles to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Ee)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.