Description

2-((3-Bromo-2-Oxopropyl)Thio)-Adenosine 3'5'-Cyclic Monophosphate is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), a crucial secondary messenger in cellular signaling pathways. This compound is specifically engineered as a potent and cell-permeable activator of protein kinase A (PKA), making it an indispensable tool for advanced biochemical and pharmacological research. It is primarily utilized by research scientists and pharmaceutical developers in the fields of cell biology, signal transduction studies, and drug discovery to investigate and modulate intracellular processes.

Application

• Biochemical Research: As a high-potency, membrane-permeable PKA activator for studying cAMP-dependent signaling cascades in vitro and in cell culture models.
• Pharmaceutical Development: Used as a reference standard and pharmacological tool compound in the discovery of drugs targeting PKA-related disorders, such as certain cancers and heart diseases.
• Cell Signaling Studies: Essential for investigating the role of PKA in cellular functions including metabolism, gene expression, and ion channel regulation.
• Neuroscience Research: Applied in studies of synaptic plasticity, memory formation, and neurotransmitter release where PKA plays a critical modulatory role.
• Enzyme Kinetics: Serves as a substrate analog or activator in enzymatic assays to study PKA kinetics and inhibitor screening.

Basic Information

Product Name	2-((3-Bromo-2-Oxopropyl)Thio)-Adenosine 3'5'-Cyclic Monophosphate
CAS No.	124379-89-1
Molecular Formula	C₁₃H₁₅BrN₅O₇PS
Molecular Weight	512.23 g/mol
Synonyms	8-Br-cAMP-S; 8-Bromo-cAMP thioether; 2-[(3-Bromo-2-oxopropyl)thio]adenosine-3',5'-cyclic monophosphate; 8-Bromo-cyclic AMP S-derivative; 8-Br-cAMP-S, cell-permeable; (8-Bromoadenosine-3',5'-cyclic monophosphorothioate), 2-[(3-bromo-2-oxopropyl)thio]-, Sp-isomer; Protein Kinase A Activator (8-Br-cAMP based); BrcAMPS
EINECS	Contact for details

Quality Control

Our 2-((3-Bromo-2-Oxopropyl)Thio)-Adenosine 3'5'-Cyclic Monophosphate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, utilizing techniques such as HPLC, NMR, and mass spectrometry to verify the chemical integrity and biological activity of this specialized research biochemical.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.