Description

Scorpion Toxin Aah It2 CAS NO 124354-86-5 is a highly purified, biologically active peptide toxin isolated from the venom of the scorpion *Androctonus australis hector*. This compound is a critical research tool for studying voltage-gated sodium channels (Nav channels), which are pivotal in neuronal signaling and a major target for pharmaceutical development. It is essential for neuroscientists, pharmacologists, and toxicologists engaged in ion channel research, drug discovery for neurological disorders, and the development of novel bio-insecticides.

Application

• Neuroscience Research: As a specific modulator of Nav1.2 and Nav1.6 sodium channel subtypes for electrophysiological studies.
• Drug Discovery & Pharmacology: High-throughput screening (HTS) for identifying novel analgesics, anticonvulsants, or neuroprotective agents targeting sodium channels.
• Toxicology & Venom Studies: Used as a reference standard for characterizing scorpion venom composition and studying toxin mechanisms of action.
• Biochemical Assay Development: Key component in developing binding assays (e.g., radioligand or fluorescence-based) to study channel-ligand interactions.
• Academic & Institutional Research: Fundamental research into the structure-function relationships of peptide toxins and ion channel gating.
• Agrochemical Research: Investigation of potential leads for next-generation, selective insecticides targeting insect sodium channels.

Basic Information

Item	Details
Product Name	Scorpion Toxin Aah It2
CAS No.	124354-86-5
Molecular Formula	C184H281N53O52S7
Molecular Weight	~4250.8 g/mol
Synonyms	AaH IT2; Toxin AahIt2; Androctonus australis hector Insect Toxin 2; Sodium channel neurotoxin; Nav1.2 channel modulator; Scorpion α-toxin AaH IT2; CAS 124354-86-5; UNII-7F9L2768QJ
EINECS	Contact for details

Quality Control

Every batch of Scorpion Toxin Aah It2 is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Our quality commitment includes identity confirmation by mass spectrometry (MS) and purity assessment by reverse-phase HPLC. Certificates of Analysis (COA) detailing batch-specific purity, potency, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to minimize freeze-thaw cycles. This product is hygroscopic (moisture-sensitive) and easily oxidized; handle under inert atmosphere when possible and use desiccants.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Biological Activity (Cell-based assay)	Activity confirmed vs. reference standard
Endotoxin Level (LAL)	< 1.0 EU/µg
Water Content (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.