Description

Scorpion Toxin Aah It1 CAS NO 124354-85-4 is a highly purified, biologically active peptide toxin isolated from the venom of the North African scorpion *Androctonus australis hector*. This compound is a critical tool in neuroscience and pharmacology research, specifically targeting voltage-gated sodium channels. It is primarily utilized by academic, pharmaceutical, and biotechnology research institutions for studying ion channel function, neurotoxin mechanisms, and developing novel therapeutic agents or diagnostic tools.

Application

• Neuroscience Research: As a selective modulator of voltage-gated sodium channels (Nav channels) for electrophysiological studies and channel characterization.
• Pharmacological Studies: Used in the investigation of pain pathways, neurological disorders, and the development of new analgesic or neuroprotective drug candidates.
• Toxin-Antibody Interaction Studies: Serves as a key antigen for the development and validation of diagnostic assays and antivenoms.
• Ion Channel Drug Discovery: A high-purity reference standard in screening platforms to identify novel channel blockers or modulators.
• Biochemical Reagent: Used in protein-protein interaction studies and structural biology to understand toxin-receptor binding sites.
• Safety and Efficacy Testing: Employed in quality control and bioactivity assessment of related biopharmaceutical products.

Basic Information

Product Name	Scorpion Toxin Aah It1
CAS No.	124354-85-4
Molecular Formula	C254H398N74O73S8 (Approx.)
Molecular Weight	~ 5850 Da (Approx.)
Synonyms	AaH IT1; Toxin Aah It1; Androctonus australis Hector Insect Toxin 1; Anti-Insect Toxin 1; AaH IT; Sodium Channel Neurotoxin; Scorpion Venom Peptide; CAS 124354-85-4
EINECS	Contact for details

Quality Control

Every batch of Scorpion Toxin Aah It1 is produced and analyzed under strict quality protocols to ensure the highest standards of purity and biological activity for research applications. Our products undergo rigorous quality testing, including multiple orthogonal analytical methods, to ensure batch-to-batch consistency and compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and bioactivity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed under anhydrous conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Biological Activity	Confirmed by functional assay (e.g., insect sodium channel assay)
Endotoxin Level	< 1.0 EU/mg
Solubility	Soluble in water or appropriate aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.