Description

1-(3-Iodophenyl)Cyclopropanecarbonitrile is a versatile and high-value iodinated aromatic nitrile building block, essential for advanced organic synthesis. Its unique structure, featuring a cyclopropane ring and an iodine substituent, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, cross-coupling reactions, and material science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, leveraging the iodine atom for further functionalization.
• Cross-Coupling Reactions: Serves as a superior substrate for palladium-catalyzed reactions like Suzuki-Miyaura, Negishi, and Sonogashira couplings to create biaryl and other conjugated systems.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers due to its rigid, aromatic core.
• Medicinal Chemistry & SAR Studies: Integral for structure-activity relationship (SAR) exploration, allowing for the introduction of the cyclopropane moiety to modulate metabolic stability and potency.
• Chemical Biology Probes: Utilized as a precursor for synthesizing labeled compounds or probes for biochemical and cellular assays.

Basic Information

Product Name	1-(3-Iodophenyl)Cyclopropanecarbonitrile
CAS No.	124276-77-3
Molecular Formula	C10H8IN
Molecular Weight	269.08 g/mol
Synonyms	3-(Cyclopropylcarbonyl)iodobenzene; 1-(3-Iodophenyl)cyclopropanecarbonitrile; 3-(Cyclopropanecarbonyl)iodobenzene; m-Iodophenyl cyclopropyl ketone nitrile; (3-Iodophenyl)cyclopropanecarbonitrile; Cyclopropane(3-iodophenyl)carbonitrile; 3-Iodobenzenecyclopropanecarbonitrile
EINECS	Contact for details

Quality Control

Our 1-(3-Iodophenyl)Cyclopropanecarbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and ISO-guided processes guarantees a reliable supply of high-purity material for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.