Description

1-(2-Methylphenyl)Cyclopropanecarbonitrile is a specialized organic nitrile building block featuring a cyclopropane ring fused to an ortho-substituted aromatic system. This unique molecular architecture makes it a valuable intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for constructing novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclopropane moiety can enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced organic materials, including liquid crystals and polymers with specific optical or electronic properties.
• Chemical Biology Probes: Utilized to build molecular probes for studying enzyme function and biological pathways due to its ability to act as a sterically constrained mimic.

Basic Information

Product Name	1-(2-Methylphenyl)Cyclopropanecarbonitrile
CAS No.	124276-51-3
Molecular Formula	C11H11N
Molecular Weight	157.21 g/mol
Synonyms	1-(2-Methylphenyl)cyclopropanecarbonitrile; o-Tolylcyclopropanecarbonitrile; 2-Methylbenzenecyclopropanecarbonitrile; 1-(o-Tolyl)cyclopropanecarbonitrile; Cyclopropanecarbonitrile, 1-(2-methylphenyl)-; 1-(2-Methylphenyl)-1-cyclopropanecarbonitrile; (2-Methylphenyl)cyclopropanecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 1-(2-Methylphenyl)Cyclopropanecarbonitrile is produced and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee reliable and reproducible results in your synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.