Description

(D-Phe6,Leu-Nhet13,Des-Met14)-Bombesin (6-14) is a synthetic peptide analog derived from the C-terminal region of the bombesin peptide, featuring specific amino acid substitutions and modifications. This compound is of significant interest for its role as a potent and selective ligand for bombesin receptor subtypes, particularly in research applications. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neurobiology, oncology, and receptor pharmacology studies to investigate cellular signaling pathways and develop targeted therapeutic agents.

Application

• Biomedical Research: As a critical tool for studying the function and distribution of gastrin-releasing peptide (GRP) and neuromedin B (NMB) receptors in various tissues.
• Oncology Research: Used in preclinical studies to explore the role of bombesin-like peptides in tumor growth, proliferation, and as a potential vector for targeted cancer imaging and therapy.
• Neuropharmacology: Investigation of central and peripheral nervous system functions, including satiety, thermoregulation, and smooth muscle contraction.
• Drug Discovery: Serves as a reference standard and a lead compound for the design and development of novel receptor agonists or antagonists.
• Diagnostic Agent Development: Potential use in the development of radiolabeled probes for positron emission tomography (PET) or single-photon emission computed tomography (SPECT) imaging.
• Signal Transduction Studies: Elucidation of G-protein coupled receptor (GPCR) activation mechanisms and downstream intracellular signaling cascades.

Basic Information

Product Name	(D-Phe6,Leu-Nhet13,Des-Met14)-Bombesin (6-14)
CAS No.	124199-90-2
Molecular Formula	C58H86N16O13
Molecular Weight	1199.4 g/mol
Synonyms	Bombesin (6-14), [D-Phe6, Leu13 ψ(CH2NH)Leu14]-; [D-Phenylalanine6,Leu13 ψ(CH2NH)Leu14]-Bombesin(6-14); Des-Met14-Bombesin(6-14) analog; Bombesin receptor ligand; GRP receptor antagonist analog; Neuromedin B receptor ligand; H-D-Trp-Ala-Val-Gly-His-D-Phe-Leu-NH-CH2-Leu-NH2
EINECS	Contact for details

Quality Control

Our (D-Phe6,Leu-Nhet13,Des-Met14)-Bombesin (6-14) is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.