Description

D-Aspartic Acid, n-[(1,1-Dimethylethoxy)Carbonyl]-, 4-Methyl Ester is a protected derivative of D-aspartic acid, a non-proteinogenic amino acid enantiomer, featuring a tert-butoxycarbonyl (Boc) protecting group on the amine and a methyl ester on the carboxylate. This compound matters as a crucial chiral building block and synthetic intermediate, offering high purity and defined stereochemistry essential for advanced organic synthesis. It is primarily needed by pharmaceutical R&D teams, peptide chemists, and fine chemical manufacturers for applications in drug discovery, the synthesis of bioactive peptides, and the preparation of complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly those targeting neurological and hormonal pathways.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-aspartic acid residue into peptide chains, enabling the study of structure-activity relationships.
• Protecting Group Chemistry: Serves as a model compound in methodological development for the selective introduction and removal of Boc (tert-butoxycarbonyl) protecting groups.
• Biochemical Research: Employed in enzymatic studies and as a standard for analytical method development (e.g., HPLC, LC-MS) for chiral amino acid analysis.
• Fine Chemical Production: Acts as a precursor for the synthesis of more complex, high-value specialty chemicals and catalysts used in asymmetric synthesis.

Basic Information

Item	Details
Product Name	D-Aspartic Acid, n-[(1,1-Dimethylethoxy)Carbonyl]-, 4-Methyl Ester
CAS No.	124184-67-4
Molecular Formula	C10H17NO6
Molecular Weight	247.25 g/mol
Synonyms	Boc-D-Asp(OMe)-OH; (R)-2-((tert-Butoxycarbonyl)amino)succinic acid 4-methyl ester; Boc-D-Aspartic acid 4-methyl ester; N-Boc-D-aspartic acid 4-methyl ester; Methyl (R)-2-((tert-butoxycarbonyl)amino)succinate; D-Aspartic acid, N-(tert-butoxycarbonyl)-, 4-methyl ester; tert-Butyloxycarbonyl-D-aspartic acid β-methyl ester
EINECS	Contact for details

Quality Control

Our D-Aspartic Acid, n-[(1,1-Dimethylethoxy)Carbonyl]-, 4-Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting standards for synthetic intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.