Description

(R)-n-Boc-N,n-Dimethyl-L-Prolinamide is a high-purity, chiral proline derivative widely used as a critical building block in advanced organic synthesis. Its value lies in providing a protected, functionalized scaffold essential for constructing complex molecules with defined stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) targets.
• Peptidomimetics & Constrained Peptides: Serves as a proline surrogate to introduce conformational rigidity and modify the biological activity of peptide-based drug candidates.
• Asymmetric Catalysis: Used as a precursor for chiral ligands or organocatalysts in stereoselective synthesis.
• Chemical Biology & Proteomics: Employed in the synthesis of specialized probes and inhibitors for studying enzyme function and protein-protein interactions.
• Academic & Industrial R&D: A versatile building block for method development and the synthesis of complex natural product analogs and chemical libraries.

Basic Information

Product Name	(R)-n-Boc-N,n-Dimethyl-L-Prolinamide
CAS No.	124072-81-7
Molecular Formula	C₁₃H₂₄N₂O₃
Molecular Weight	256.34 g/mol
Synonyms	(R)-1-[(tert-Butoxycarbonyl)-N,N-dimethyl]pyrrolidine-2-carboxamide; (R)-N-Boc-N,N-Dimethylprolinamide; (R)-N-Boc-2-(Dimethylcarbamoyl)pyrrolidine; (R)-N-(tert-Butoxycarbonyl)-N,N-dimethyl-L-prolinamide; tert-Butyl (R)-2-(dimethylcarbamoyl)pyrrolidine-1-carboxylate; (R)-Boc-N,N-Dimethylproline Amide; (R)-Boc-Dimethylprolinamide
EINECS	Contact for details

Quality Control

Our (R)-n-Boc-N,n-Dimethyl-L-Prolinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.