Description

Almokalant CAS NO 123955-10-2 is a selective potassium channel blocker belonging to the class III antiarrhythmic agents. This compound is of significant interest in pharmaceutical research and development for its potential to modulate cardiac electrophysiology. It is primarily utilized by researchers and manufacturers in the life sciences sector for preclinical studies and as a reference standard in analytical chemistry.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified material for analytical method development, validation, and quality control (QC) in drug substance and product testing.
• Cardiovascular Research: Serves as a critical pharmacological tool in preclinical studies investigating cardiac arrhythmia mechanisms and the efficacy of antiarrhythmic therapies.
• Biochemical Assay Development: Employed in in vitro assays to study the function and inhibition of specific potassium ion channels (e.g., IKr).
• Active Pharmaceutical Ingredient (API) Intermediate: Functions as a key synthetic intermediate in the development and production pathways for novel therapeutic agents.
• Metabolite Identification Studies: Used in ADME (Absorption, Distribution, Metabolism, and Excretion) research to identify and characterize metabolic pathways.

Basic Information

Product Name	Almokalant
CAS No.	123955-10-2
Molecular Formula	C22H28N2O4
Molecular Weight	384.47 g/mol
Synonyms	Almokalant; H 234/09; (R)-N-[3-[(4-[(4-Methoxyphenyl)sulfonyl]phenyl)methyl]-1H-indol-7-yl]-3-methyl-2-butenamide; 4-[[[4-(Methylsulfonyl)phenyl]methyl]-1H-indol-7-yl]carbamic acid (R)-3-methyl-2-butenyl ester
EINECS	Contact for details

Quality Control

Every batch of Almokalant is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support research and regulatory requirements. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and other critical specifications as determined by validated methods such as HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.