Description

Biglycan is a small leucine-rich proteoglycan (SLRP) that plays a crucial structural and signaling role in the extracellular matrix. Its importance lies in its ability to regulate collagen fibrillogenesis, influence cell proliferation and differentiation, and modulate growth factor activity. This makes it a valuable research reagent for scientists in the fields of connective tissue biology, bone and cartilage research, oncology, and cardiovascular studies.

Application

• Biomedical Research: Used as a key reagent to study extracellular matrix assembly, cell-matrix interactions, and tissue development.
• Connective Tissue Studies: Essential for investigating the molecular mechanisms underlying bone, cartilage, tendon, and skin biology.
• Cancer Research: Employed to explore its dual role as a tumor suppressor and promoter in various cancer models, including osteosarcoma and breast cancer.
• Cardiovascular Research: Applied in studies of heart valve development, atherosclerosis, and vascular calcification.
• Signal Transduction Analysis: Used to investigate its interactions with growth factors like TGF-β and BMP, influencing cellular signaling pathways.
• Inflammation and Immunity: Studied for its role as an endogenous ligand for toll-like receptors (TLRs) in innate immune responses.

Basic Information

Product Name	Biglycan
CAS No.	123939-84-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	BGN; Bone/Cartilage Proteoglycan I; DSPG1; PG-I; Proteoglycan I; SLRP; Small Leucine-Rich Proteoglycan Biglycan; Biglycan Core Protein
EINECS	Contact for details

Quality Control

Our Biglycan is produced and handled under stringent conditions to ensure batch-to-batch consistency and biological activity. Each lot is subjected to rigorous quality testing, including purity analysis and functional characterization. A comprehensive Certificate of Analysis (COA) detailing specifications such as purity, endotoxin levels, and biological activity is provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture uptake. For optimal performance, aliquot the reconstituted product to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Endotoxin Level	< 1.0 EU/μg
Biological Activity	Determined by cell-based assay
Solubility	Soluble in water or appropriate buffer
Source	Recombinant (e.g., Human, expressed in mammalian cells)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.