Description

1-Butoxy-3,5-Difluorobenzene is a high-purity fluorinated aromatic ether building block. This compound is valued for its unique combination of an alkoxy substituent and fluorine atoms, which impart specific electronic and steric properties to molecular structures. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical and advanced materials sectors for the synthesis of complex organic molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of novel herbicides and pesticides, where the difluorobenzene moiety enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic display materials, contributing to the tuning of dielectric anisotropy and charge transport properties.
• Polymer Modification: Acts as a monomer or functionalization agent for engineering plastics and specialty polymers to improve chemical resistance and thermal stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the butoxy-difluorophenyl group into more complex architectures.

Basic Information

Product Name	1-Butoxy-3,5-Difluorobenzene
CAS No.	123843-64-1
Molecular Formula	C₁₀H₁₂F₂O
Molecular Weight	186.20 g/mol
Synonyms	3,5-Difluorophenyl butyl ether; Butyl 3,5-difluorophenyl ether; 1-Butoxy-3,5-difluorobenzene; 3,5-Difluoro-1-butoxybenzene; 3,5-Difluorophenyl butyl ether; Butyl 3,5-difluorophenyl ether; 3,5-Difluorophenol butyl ether
EINECS	Contact for details

Quality Control

Every batch of 1-Butoxy-3,5-Difluorobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC/HPLC is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.08 g/cm³
Refractive Index (n20D)	~1.460 - 1.470

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.