Description

24,24-Difluoro-1,25-Dihydroxy-26,27-Dimethylvitamin D3 is a potent, fluorinated analog of the active form of vitamin D, designed for enhanced metabolic stability and targeted biological activity. This compound is critical for advanced research and development in endocrinology and oncology, where precise modulation of vitamin D receptor pathways is required. It serves as a key high-purity intermediate for pharmaceutical innovators and research institutions developing novel therapeutics for bone disorders, immune modulation, and cancer.

Application

• Pharmaceutical Intermediate: Synthesis of next-generation vitamin D receptor (VDR) agonists and antagonists for clinical research.
• Biochemical Research: A critical tool compound for studying VDR signaling, gene regulation, and cell differentiation mechanisms.
• Oncology Research: Investigation of anti-proliferative and pro-differentiation effects in various cancer cell lines.
• Metabolic Studies: Exploration of calcium and phosphate homeostasis in preclinical models.
• Reference Standard: Used as a high-purity analytical standard for quality control in API manufacturing.
• Drug Discovery: A building block for creating novel analogs with improved pharmacokinetic profiles.

Basic Information

Product Name	24,24-Difluoro-1,25-Dihydroxy-26,27-Dimethylvitamin D3
CAS No.	123836-13-5
Molecular Formula	C₂₉H₄₄F₂O₃
Molecular Weight	478.66 g/mol
Synonyms	1,25-Dihydroxy-24,24-difluoro-26,27-dimethylcholecalciferol; 24,24-Difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D₃; 24,24-Difluoro-1α,25-dihydroxy-26,27-dimethylcholecalciferol; 1α,25-Dihydroxy-24,24-difluoro-26,27-dimethylvitamin D3; Falecalcitriol analog; 24,24-Difluoro Falecalcitriol precursor; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4S)-4-ethyl-1,5-dimethylhepta-2,6-dien-1-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-2-(trifluoromethyl)cyclohexane-1,3-diol (IUPAC)
EINECS	Contact for details

Quality Control

Our 24,24-Difluoro-1,25-Dihydroxy-26,27-Dimethylvitamin D3 is manufactured under strict quality systems suitable for research and development use. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing comprehensive analytical results from HPLC, NMR, and MS are provided to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.