Description

Bombesin (6-14), D-Phe(6)-Leu(13)-Psi(Ch2Nh)-Phe(14)- is a synthetic peptide analog of the natural bombesin sequence, featuring a reduced peptide bond (Psi) modification that enhances its metabolic stability and receptor binding affinity. This engineered structure is critical for advanced research into bombesin receptor subtypes, particularly in the study of cellular signaling pathways and receptor-ligand interactions. It serves as a valuable tool for pharmaceutical R&D teams and academic researchers focused on oncology, neurobiology, and diagnostic imaging probe development.

Application

• Biomedical Research: Used as a key reference standard and probe in studies of gastrin-releasing peptide (GRP) receptor and neuromedin B (NMB) receptor signaling and distribution.
• Oncology Research: Investigated for its role in cancer cell proliferation, particularly in cancers where bombesin receptors are overexpressed, such as prostate, breast, and small-cell lung carcinoma.
• Drug Discovery: Serves as a lead compound or template for the design and development of novel therapeutic agents targeting bombesin receptor pathways.
• Diagnostic Development: Utilized in the development of radiolabeled (e.g., with 68Ga, 99mTc) analogs for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging.
• Neuroscience Studies: Applied in research exploring the role of bombesin-like peptides in the central nervous system, including studies on satiety, stress response, and thermoregulation.
• In Vitro Assays: Employed in competitive binding assays, receptor autoradiography, and functional cell-based assays to characterize receptor pharmacology.

Basic Information

Product Name	Bombesin (6-14), D-Phe(6)-Leu(13)-Psi(Ch2Nh)-Phe(14)-
CAS No.	123769-98-2
Molecular Formula	C57H81N15O12
Molecular Weight	1140.34 g/mol
Synonyms	D-Phe6, Leu13 ψ(CH2NH)Phe14-Bombesin(6-14); [D-Phe6, Leu13 ψ(CH2NH)Phe14]-Bombesin(6-14); Bombesin (6-14) pseudopeptide; Bombesin receptor antagonist analog; Reduced peptide bond bombesin analog; GRP receptor ligand; BBN(6-14) analog
EINECS	Contact for details

Quality Control

Our Bombesin (6-14) analog is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.