Description

Fmoc-5-Aminopentanoic Acid CAS NO 123622-48-0 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). It serves as a crucial building block for introducing a 5-aminopentanoic acid (norvaline-like) spacer with an orthogonal Fmoc protecting group, enabling the controlled elongation of complex peptide chains. This compound is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic probes, and novel biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated or manual synthesis of custom peptides.
• Therapeutic Peptide Development: Incorporation of a flexible linker or spacer arm in the structure of peptide-based drug candidates.
• Bioconjugation and Labeling: Facilitating the covalent attachment of peptides to other molecules, surfaces, or fluorophores via its carboxylic acid group.
• Combinatorial Chemistry Libraries: Used as a versatile scaffold for generating diverse arrays of compounds in drug discovery platforms.
• Material Science: Synthesis of peptide-polymer hybrids or bio-inspired materials requiring precise amino acid sequences.
• Academic and Industrial Research: A fundamental reagent for studying protein-protein interactions, enzyme substrates, and receptor ligands.

Basic Information

Product Name	Fmoc-5-Aminopentanoic Acid
CAS No.	123622-48-0
Molecular Formula	C₂₀H₂₁NO₄
Molecular Weight	339.39 g/mol
Synonyms	Fmoc-5-Aminovaleric Acid; N-(9-Fluorenylmethoxycarbonyl)-5-aminopentanoic Acid; 5-[(9H-Fluoren-9-ylmethoxy)carbonylamino]pentanoic Acid; Fmoc-NH-(CH₂)₄-COOH; N-α-Fmoc-δ-aminovaleric acid; Fmoc-δ-Ava-OH; Fmoc-Ava-OH; N-Fmoc-5-aminopentanoic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-5-Aminopentanoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced pharmaceutical applications, and specifications can be tailored to meet specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.