Description

(S)-(-)-o-Desmethylcarvedilol is a key chiral intermediate and the major active metabolite of the widely prescribed cardiovascular drug carvedilol. This compound matters for its critical role in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of novel therapeutic agents. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery, metabolite synthesis, and analytical method development.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and identification of carvedilol metabolites in bioanalytical studies, pharmacokinetic profiling, and drug metabolism research.
• Active Pharmaceutical Ingredient (API) Intermediate: Used as a high-purity chiral building block in the synthesis and process development of advanced carvedilol derivatives and next-generation β-blockers.
• Metabolite Research: Essential for in vitro and in vivo studies to understand the pharmacological activity, safety profile, and clearance pathways of carvedilol's primary metabolites.
• Analytical Method Development: Employed as a critical standard for developing and validating HPLC, LC-MS, and other chromatographic methods in quality control and bioanalytical laboratories.
• Impurity Profiling: Used to identify, characterize, and control related substance impurities during the manufacturing and stability testing of carvedilol API and finished dosage forms.

Basic Information

Product Name	(S)-(-)-o-Desmethylcarvedilol
CAS No.	123372-13-4
Molecular Formula	C₂₃H₂₆N₂O₄
Molecular Weight	394.47 g/mol
Synonyms	(S)-(-)-o-Desmethyl Carvedilol; (S)-o-Desmethylcarvedilol; (S)-4-(3-Carbazol-4-yloxy-2-hydroxypropylamino)-6,7-dimethoxyquinazolin-2(1H)-one; (S)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol Metabolite; Carvedilol Metabolite M4 (S-Form); (S)-BM 910228
EINECS	Contact for details

Quality Control

Our (S)-(-)-o-Desmethylcarvedilol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.