Description

H-Cit-Amc Hbr CAS NO 123314-39-6 is a specialized chemical intermediate, specifically a protected amino acid derivative. This compound is critical for advanced organic synthesis, particularly in the construction of complex peptide chains where precise control over reactivity is required. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents and biochemical tools.

Application

• Peptide Synthesis: Serves as a key building block in solid-phase and solution-phase peptide synthesis, especially for introducing citrulline or other modified amino acid residues.
• Pharmaceutical Research: Used in the research and development of new drug candidates, including protease inhibitors and bioactive peptides.
• Bioconjugation: Acts as a linker or spacer molecule in the conjugation of peptides to other biomolecules, dyes, or solid supports.
• Chemical Biology: Employed in the synthesis of probes and tools for studying enzyme activity and protein-protein interactions.
• API Intermediate: Functions as a high-purity intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for methodological development in synthetic organic chemistry.

Basic Information

Product Name	H-Cit-Amc Hbr
CAS No.	123314-39-6
Molecular Formula	C10H19BrN4O4
Molecular Weight	339.19 g/mol
Synonyms	H-Cit-AMC hydrobromide; N-α-(tert-Butoxycarbonyl)-N-δ-[(benzyloxy)carbonyl]-L-citrulline 7-amido-4-methylcoumarin hydrobromide; Boc-Cit(Z)-AMC·HBr; L-Citrulline, N2-[(1,1-dimethylethoxy)carbonyl]-N5-[(phenylmethoxy)carbonyl]-, 7-(4-methyl-2-oxo-2H-1-benzopyran-7-yl) ester, hydrobromide; Boc-Cit(Z)-AMC HBr; Fluorogenic peptide substrate; Citrulline-AMC derivative
EINECS	Contact for details

Quality Control

Our H-Cit-Amc Hbr is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Quality is assured through analytical techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.