Description

(R)-n-Boc-α-Ethylalanine, 98% Ee, 98% CAS NO 123254-58-0 is a high-purity, non-natural amino acid derivative featuring a Boc-protected amine group and a chiral center with high enantiomeric excess. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling the development of pharmaceuticals with enhanced biological activity and metabolic stability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors, receptor agonists/antagonists, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce a sterically hindered, non-proteinogenic amino acid residue, altering peptide conformation and stability.
• Protease Inhibitor Development: Serves as a core structural component in the design of potent and selective inhibitors for various proteolytic enzymes.
• Chemical Biology Research: Employed in the synthesis of labeled probes, peptide libraries, and molecular tools for studying protein-protein interactions and enzyme mechanisms.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in asymmetric catalytic reactions to construct other complex chiral molecules.

Basic Information

Product Name	(R)-n-Boc-α-Ethylalanine, 98% Ee, 98%
CAS No.	123254-58-0
Molecular Formula	C₁₀H₁₉NO₄
Molecular Weight	217.26 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-2-ethylpropanoic Acid; (R)-2-(Boc-amino)-2-ethylpropionic Acid; Boc-D-α-Ethylalanine; (R)-N-Boc-2-Amino-2-ethylpropanoic Acid; (R)-N-(tert-Butoxycarbonyl)-2-amino-2-ethylpropanoic Acid; (R)-Boc-Aib(Et)-OH; (R)-Boc-α-Ethylalanine
EINECS	Contact for details

Quality Control

Every batch of (R)-n-Boc-α-Ethylalanine is subjected to rigorous analytical testing to ensure it meets the specified purity and enantiomeric excess (Ee) standards. Our quality assurance protocols are designed to support cGMP (current Good Manufacturing Practice) compliance for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), chiral purity (by chiral HPLC), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.