Description

H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Oh is a synthetic, cell-penetrating peptide (CPP) sequence, also known as the HIV-1 Tat (48-60) fragment. This compound is a crucial research tool for studying intracellular delivery mechanisms and developing novel therapeutic vectors. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on drug delivery systems, gene therapy, and proteomics. The product is supplied under strict quality control to ensure batch-to-batch consistency for critical research applications.

Application

• Drug Delivery Research: As a model cell-penetrating peptide (CPP) for studying the translocation of bioactive molecules (e.g., proteins, nucleic acids, drugs) across cell membranes.
• Gene Therapy Vector Development: Used to conjugate with oligonucleotides or plasmids to enhance cellular uptake and nuclear localization for gene editing and silencing applications.
• Intracellular Imaging: Conjugated with fluorescent dyes or quantum dots to track cellular entry pathways and intracellular trafficking in live-cell imaging studies.
• Vaccine Adjuvant Design: Investigated for its ability to deliver antigenic epitopes into antigen-presenting cells to potentiate immune responses.
• Neuroscience Research: Employed to deliver neuroprotective agents or diagnostic tools across the blood-brain barrier in preclinical models.
• Bioconjugation & Probe Synthesis: Serves as a backbone for creating multifunctional probes and bioconjugates due to its multiple reactive amino acid side chains.
• Antimicrobial Peptide (AMP) Studies: Analyzed for derived sequences with potential antimicrobial or anticancer activity.
• Standard & Reference Material: Used as a high-purity analytical standard in peptide characterization and quality control laboratories.

Basic Information

Product Name	H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Oh
CAS No.	123251-89-8
Molecular Formula	C58H118N34O12
Molecular Weight	1387.75 g/mol
Synonyms	Tat (48-60); HIV-1 Tat Protein (48-60); GRKKRRQRRRPPQ; Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg; Cell-Penetrating Peptide Tat (48-60); HIV-1 Trans-Activating Regulatory Protein (48-60); TAT Peptide; CPP Tat Fragment
EINECS	Contact for details

Quality Control

Our H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Oh is manufactured under controlled conditions to meet the stringent requirements of research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with internal specifications. For specific regulatory needs, please contact our technical support team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	± 10% of theoretical
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.