Description

Cbz-2-Bromo-D-Phenylalanine CAS NO 123098-44-2 is a protected, non-natural amino acid derivative featuring a benzyloxycarbonyl (Cbz) protecting group and a bromine substituent on the aromatic ring. This compound is a critical chiral building block in organic synthesis, enabling the precise construction of complex peptide-based molecules and pharmaceutical intermediates. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, enzyme substrates, and other bioactive peptide mimetics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a bromo-functionalized phenylalanine residue, allowing for further site-specific modifications via cross-coupling reactions.
• Chemical Biology Research: Serves as a precursor for developing activity-based probes, affinity labels, or labeled peptides for studying enzyme mechanisms and protein interactions.
• Ligand and Catalyst Development: The bromine atom provides a handle for palladium-catalyzed coupling reactions (e.g., Suzuki, Sonogashira), enabling the creation of diverse chemical libraries and chiral ligands.
• Agrochemical Research: Potential building block for the development of novel, biologically active compounds with specific stereochemical requirements.

Basic Information

Product Name	Cbz-2-Bromo-D-Phenylalanine
CAS No.	123098-44-2
Molecular Formula	C₁₇H₁₆BrNO₄
Molecular Weight	378.22 g/mol
Synonyms	N-Carbobenzoxy-2-bromo-D-phenylalanine; (R)-2-((Benzyloxy)carbonyl)amino)-3-(2-bromophenyl)propanoic acid; Z-2-Br-D-Phe-OH; Nα-Cbz-2-Bromo-D-phenylalanine; N-Cbz-(2-Br)-D-Phe; Benzyl (2R)-2-[[(2-bromophenyl)methyl]amino]-3-phenylpropanoate (related ester); Boc-2-Bromo-D-phenylalanine (related Boc-protected analog); 2-Bromo-D-phenylalanine Cbz derivative
EINECS	Contact for details

Quality Control

Our Cbz-2-Bromo-D-Phenylalanine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, confirming compliance with customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.