Description

(R)-o-Desmethyl Naproxen is a high-purity chiral intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) naproxen. This compound is of significant value in pharmaceutical research and development, particularly for studying drug metabolism and as a critical building block for synthesizing novel, targeted anti-inflammatory agents. It is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on chiral chemistry, pharmacokinetics, and the development of advanced therapeutic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel NSAIDs and other therapeutic agents.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical studies (HPLC, LC-MS) to quantify naproxen metabolites in pharmacokinetic and pharmacodynamic research.
• Chiral Resolution Studies: Employed in method development for separating enantiomers and studying stereoselective metabolism.
• Biochemical Research: Utilized in in-vitro and in-vivo studies to investigate the metabolic pathways and mechanisms of action of naproxen.
• Impurity Standard: Serves as a certified reference material (CRM) for quality control and regulatory compliance in naproxen API manufacturing.
• Academic Research: A valuable compound for university and institutional research in medicinal chemistry and pharmacology.

Basic Information

Product Name	(R)-o-Desmethyl Naproxen
CAS No.	123050-98-6
Molecular Formula	C₁₃H₁₄O₃
Molecular Weight	218.25 g/mol
Synonyms	(R)-6-Methoxy-α-methyl-2-naphthaleneacetic Acid; (R)-Desmethylnaproxen; (R)-DMN; (2R)-2-(6-Hydroxy-2-naphthyl)propanoic Acid; (R)-Naproxen Metabolite; (R)-O-Desmethylnaproxen; (R)-6-Hydroxy-α-methyl-2-naphthaleneacetic Acid
EINECS	Contact for details

Quality Control

Our (R)-o-Desmethyl Naproxen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for pharmaceutical research. A detailed Certificate of Analysis (COA) providing full characterization data—including assay, enantiomeric excess, and impurity profile—is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.