Description

2-(3-Bromo-5-Methoxyphenyl)Acetonitrile is a versatile brominated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing substituted phenyl or heterocyclic moieties.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators where the bromo-methoxy phenyl group is a key structural element.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and advanced polymers requiring specific bromo-functionalized aromatic units.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form carbon-carbon bonds.
• Nitrile Transformation Chemistry: The nitrile group can be hydrolyzed to carboxylic acids, reduced to amines, or converted into tetrazoles and other heterocycles, expanding its utility.

Basic Information

Product Name	2-(3-Bromo-5-Methoxyphenyl)Acetonitrile
CAS No.	123018-27-9
Molecular Formula	C9H8BrNO
Molecular Weight	226.07 g/mol
Synonyms	(3-Bromo-5-methoxyphenyl)acetonitrile; 2-(3-Bromo-5-methoxyphenyl)ethanenitrile; 3-Bromo-5-methoxybenzyl cyanide; 3'-Bromo-5'-methoxyacetonitrile; 3-Bromo-5-methoxyphenylacetonitrile; α-Cyano-3-bromo-5-methoxytoluene; 3-Bromo-5-methoxybenzeneacetonitrile
EINECS	Contact for details

Quality Control

Our 2-(3-Bromo-5-Methoxyphenyl)Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The container should be kept tightly sealed in a dry environment to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.