Description

Fmoc-Hyp(Tbu)-Oh CAS NO 122996-47-8 is a protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled and efficient incorporation of hydroxyproline, a key amino acid for imparting structural stability and biological activity in therapeutic peptides. It is an essential building block for research and development laboratories, pharmaceutical companies, and CROs focused on peptide-based drug discovery, particularly for targets involving collagen-like structures.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected building block for the automated synthesis of complex peptides.
• Pharmaceutical R&D: For the development of novel peptide therapeutics, hormones, and enzyme inhibitors where hydroxyproline is a critical structural component.
• Collagen-Mimetic Peptides: Essential for synthesizing peptides that mimic the triple-helical structure of collagen for biomedical and materials science applications.
• Glycopeptide Synthesis: Serves as a precursor for the synthesis of glycosylated peptides, important in studying cell signaling and developing biologics.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify new bioactive compounds.
• Academic Research: A fundamental reagent for studying protein folding, peptide stability, and structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-Hyp(Tbu)-Oh
CAS No.	122996-47-8
Molecular Formula	C24H27NO6
Molecular Weight	425.48 g/mol
Synonyms	Fmoc-Hyp(OtBu)-OH; Fmoc-trans-4-Hydroxy-L-proline(t-butyl ester); N-(9-Fluorenylmethoxycarbonyl)-4-hydroxy-L-proline tert-butyl ester; Fmoc-4-hydroxy-L-proline tert-butyl ester; Fmoc-L-hydroxyproline(tBu)-OH; N-α-Fmoc-4(R)-hydroxy-L-proline tert-butyl ester; (2S,4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(tert-butoxy)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Hyp(Tbu)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards to support our customers' needs in GMP and non-GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation	-40.0° to -44.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.