Description

Fmoc-Lys(Teoc)-Oh is a protected amino acid derivative of significant importance in solid-phase peptide synthesis (SPPS). This compound is specifically engineered to provide orthogonal protection for the lysine side chain, enabling the sequential and controlled assembly of complex peptides. It is an essential building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing peptide-based therapeutics, diagnostic agents, and research biochemicals. Its high purity and reliable performance are critical for ensuring successful synthesis outcomes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of peptides containing lysine residues.
• Pharmaceutical Research: Used in the discovery and development of novel peptide drugs, hormones, and antimicrobial peptides.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening and drug discovery.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted therapies.
• Proteomics & Biochemical Research: Utilized in the study of protein-protein interactions and the synthesis of labeled peptide probes.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Item	Detail
Product Name	Fmoc-Lys(Teoc)-Oh
CAS No.	122903-68-8
Molecular Formula	C27H34N2O6Si
Molecular Weight	510.66 g/mol
Synonyms	Fmoc-Lys(Teoc)-OH; Nα-Fmoc-Nε-(2-(trimethylsilyl)ethoxycarbonyl)-L-lysine; Fmoc-Lys(Teco)-OH; Fmoc-L-lysine(Teoc)-OH; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-[2-(trimethylsilyl)ethoxycarbonyl]-L-lysine; (2S)-6-[[2-(Trimethylsilyl)ethoxy]carbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid; Fmoc-Lys(2-(trimethylsilyl)ethoxycarbonyl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Lys(Teoc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and GMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.5%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.