Description

Ziprasidone is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the benzisothiazolyl piperazine class. Its primary commercial value lies in its critical role as the key component in the synthesis of antipsychotic medications. This compound is essential for manufacturers in the global pharmaceutical industry engaged in the production of finished dosage forms for the treatment of schizophrenia and bipolar disorder. We supply Ziprasidone CAS NO 122883-93-6 to meet the stringent quality and regulatory demands of modern drug manufacturing.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the core active component in antipsychotic drug formulations.
• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of final drug substances.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing.
• Research & Development: Utilized in preclinical and clinical research for studying neuropharmacology and developing new therapeutic entities.
• Generic Drug Manufacturing: A key material for companies producing bioequivalent versions of branded antipsychotic medications.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs engaged in the production of solid oral dosage forms like capsules and tablets.

Basic Information

Product Name	Ziprasidone
CAS No.	122883-93-6
Molecular Formula	C21H21ClN4OS
Molecular Weight	412.94 g/mol
Synonyms	5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one; Zeldox; Geodon; CP-88059; 6-Chloro-5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-1,3-dihydro-2H-indol-2-one; 3-[2-[4-(6-Chloro-2-oxo-1,3-dihydroindol-5-yl)ethyl]piperazin-1-yl]-1,2-benzisothiazole
EINECS	Contact for details

Quality Control

Our Ziprasidone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles to support our clients' regulatory compliance for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.