Description

4-Trifluoromethyl-L-Phenylalanine Hydrochloride is a high-purity, non-natural amino acid derivative characterized by its trifluoromethylated aromatic side chain. This compound is a critical chiral building block in modern pharmaceutical research and development, offering enhanced metabolic stability and lipophilicity to peptide-based drug candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutics, including protease inhibitors and other bioactive peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of peptide-based drugs and protease inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine for optimizing drug potency and pharmacokinetic properties.
• Peptide Synthesis: Serves as a specialized, fluorinated amino acid residue in solid-phase and solution-phase peptide synthesis (SPPS).
• Chemical Biology Probes: Incorporated into peptides to create tools for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Potential intermediate in the synthesis of advanced, bioactive compounds for crop protection.
• Material Science: Exploration of fluorinated amino acids in the design of novel polymers and biomaterials.

Basic Information

Product Name	4-Trifluoromethyl-L-Phenylalanine Hydrochloride
CAS No.	122839-50-3
Molecular Formula	C10H11F3NO2 • HCl
Molecular Weight	269.65 g/mol (Free base: 233.20 g/mol)
Synonyms	(S)-2-Amino-3-[4-(trifluoromethyl)phenyl]propanoic acid hydrochloride; L-4-(Trifluoromethyl)phenylalanine HCl; F3C-Phe-OH • HCl; 4-CF3-L-Phe hydrochloride; (S)-3-(4-Trifluoromethylphenyl)alanine hydrochloride; 4-Trifluoromethylphenylalanine hydrochloride (L-form); p-Trifluoromethyl-L-phenylalanine HCl
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-L-Phenylalanine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.