Description

Gadodiamide is a non-ionic, macrocyclic gadolinium-based contrast agent. This compound is critically important in the field of diagnostic imaging, where it serves to enhance the clarity and detail of magnetic resonance imaging (MRI) scans. It is primarily needed by pharmaceutical manufacturers, diagnostic imaging centers, and research institutions developing advanced medical imaging technologies. Gadodiamide CAS NO 122795-43-1 is engineered for high stability and efficacy in clinical applications.

Application

• Magnetic Resonance Imaging (MRI) Contrast Agent: The primary and most significant application is as an intravenous contrast medium for MRI procedures, particularly for central nervous system (CNS) and body imaging to improve lesion detection and characterization.
• Angiography: Used in contrast-enhanced magnetic resonance angiography (MRA) to visualize blood vessels and assess vascular diseases.
• Oncological Imaging: Employed to enhance the visibility of tumors, aiding in the diagnosis, staging, and treatment monitoring of various cancers.
• Neurological Diagnostics: Critical for imaging the brain and spine to detect conditions such as tumors, inflammation, demyelinating diseases (e.g., multiple sclerosis), and vascular abnormalities.
• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of other specialized diagnostic agents or research compounds.
• Research & Development: Used in preclinical and clinical research studies to develop new imaging protocols and evaluate the efficacy of novel diagnostic approaches.

Basic Information

Product Name	Gadodiamide
CAS No.	122795-43-1
Molecular Formula	C16H28GdN5O8
Molecular Weight	573.66 g/mol
Synonyms	Gadodiamide; Gd-DTPA-BMA; Gadodiamide hydrate; Gadolinium diethylenetriaminepentaacetic acid bismethylamide; Omniscan (trade name); Gd-DTPA-BMA; 2-[Bis[2-[bis(carboxymethyl)amino]ethyl]amino]-N-(2-methyl-2-{[(methylcarbamoyl)methyl]amino}propyl)acetate; Gadolinium(3+) 2-[Bis[2-[bis(carboxymethyl-kappaO)amino]ethyl]amino]-N-(2-methyl-2-{[(methylcarbamoyl)methyl]amino}propyl)acetate
EINECS	Contact for details

Quality Control

Our Gadodiamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical and research applications. Certificates of Analysis (COA) are provided, detailing parameters such as assay, impurity profile, and heavy metal content. We adhere to relevant ICH guidelines and can support compliance requirements for cGMP production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
pH (1% Solution)	6.5 - 8.0
Water Content (KF)	≤ 2.0%
Heavy Metals (as Pb)	≤ 10 ppm
Free Gadolinium	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Bacterial Endotoxins	< 0.5 EU/mg
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.