Description

(1R,2S)-2-Aminocyclopentanecarboxylic Acid is a non-proteinogenic, conformationally constrained cyclic amino acid derivative. This chiral building block is of significant value in medicinal chemistry and peptide research for constructing novel molecular architectures. It serves as a critical intermediate for pharmaceutical companies and research institutions developing peptide-based therapeutics, enzyme inhibitors, and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and peptidomimetic drug discovery programs.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability, bioavailability, and receptor selectivity.
• Chiral Catalyst & Ligand Synthesis: Serves as a precursor for synthesizing chiral auxiliaries, catalysts, and ligands used in asymmetric synthesis.
• Biochemical Research: Employed in studying enzyme-substrate interactions, protein folding, and as a tool compound in molecular biology.
• Agrochemical Development: Potential intermediate for creating chiral active ingredients with specific biological activity.
• Material Science: Building block for specialty polymers and advanced materials requiring specific stereochemistry.

Basic Information

Product Name	(1R,2S)-2-Aminocyclopentanecarboxylic Acid
CAS No.	122672-46-2
Molecular Formula	C6H11NO2
Molecular Weight	129.16 g/mol
Synonyms	(1R,2S)-2-Aminocyclopentane-1-carboxylic Acid; cis-2-Aminocyclopentanecarboxylic Acid; (1R,2S)-ACPC; cis-ACPC; (1R,2S)-2-Amino-1-cyclopentanecarboxylic Acid; Cycloleucine derivative; 2-Aminocyclopentane-1-carboxylic acid, (1R,2S)-rel-
EINECS	Contact for details

Quality Control

Our (1R,2S)-2-Aminocyclopentanecarboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.