Description

Ibutilide is a class III antiarrhythmic agent, a potent and selective blocker of the rapid component of the delayed rectifier potassium current. This compound is critical for the research and development of novel cardiac therapeutics, particularly for the acute termination of atrial flutter and fibrillation. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) and finished dosage forms.

Application

• Pharmaceutical Active Ingredient (API): Serves as the key therapeutic component in the formulation of antiarrhythmic injectable medications.
• Cardiac Electrophysiology Research: A vital tool for in vitro and in vivo studies investigating mechanisms of arrhythmia and cardiac ion channel function.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development, validation, and routine testing of pharmaceutical products.
• Preclinical Development: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies during the drug development pipeline.
• Chemical Synthesis Intermediate: Acts as a building block for the synthesis of more complex chemical entities or derivative compounds in medicinal chemistry.

Basic Information

Product Name	Ibutilide
CAS No.	122647-31-8
Molecular Formula	C20H36N2O3S
Molecular Weight	384.58 g/mol
Synonyms	Ibutilide fumarate; U-70226E; (R)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide; (+)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide; 1-Butanesulfonamide, N-[4-[4-(ethyloctylamino)-1-hydroxybutyl]phenyl]-, (αR)-; Corvert (brand name)
EINECS	Contact for details

Quality Control

Our Ibutilide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C limits
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.