Description

3,5-Difluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound is valued for its role in introducing the difluorophenyl moiety, enabling the fine-tuning of molecular properties such as lipophilicity, metabolic stability, and binding affinity in target molecules. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, CNS agents, and other biologically active compounds where fluorine substitution is beneficial.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluorophenyl group can enhance activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent in medicinal chemistry and process R&D for exploring new chemical entities and optimizing synthetic routes.
• Fluorine Chemistry Studies: Used as a model compound in academic and industrial research focused on the reactivity and applications of fluorinated aromatics.

Basic Information

Product Name	3,5-Difluorophenylacetonitrile
CAS No.	122376-76-5
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	(3,5-Difluorophenyl)acetonitrile; 2-(3,5-Difluorophenyl)acetonitrile; 3,5-Difluorobenzeneacetonitrile; α-Cyano-3,5-difluorotoluene; 3,5-Difluorophenyl Cyanomethane; 122376-76-5; 3,5-DFPA
EINECS	Contact for details

Quality Control

Our 3,5-Difluorophenylacetonitrile is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.