Description

2-(4-Bromophenyl)-1,1,1-Trifluoropropan-2-Ol is a high-value fluorinated aromatic building block, distinguished by its unique combination of a bromophenyl group and a trifluoromethyl carbinol moiety. This structure makes it a versatile intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs), where the introduction of fluorine atoms is critical for modulating biological activity and physicochemical properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in CNS and oncology research, where the trifluoromethyl group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in creating advanced herbicides and fungicides, leveraging the bromine atom for further functionalization and the fluorine for improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Cross-Coupling Reactions: The aryl bromide functionality makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings to build complex biaryl systems.
• Advanced Polymer Monomers: Employed in the synthesis of specialty fluoropolymers with enhanced chemical resistance, low surface energy, and unique optical properties.
• Chemical Research & Development: A valuable tool compound for exploring new fluorination methodologies and constructing molecular libraries for screening.

Basic Information

Product Name	2-(4-Bromophenyl)-1,1,1-Trifluoropropan-2-Ol
CAS No.	122243-28-1
Molecular Formula	C9H8BrF3O
Molecular Weight	269.06 g/mol
Synonyms	1-(4-Bromophenyl)-2,2,2-trifluoroethanol; 2,2,2-Trifluoro-1-(4-bromophenyl)ethanol; α-(4-Bromophenyl)-α-(trifluoromethyl)methanol; 4-Bromo-α-(trifluoromethyl)benzenemethanol; 1-(4-Bromophenyl)-2,2,2-trifluoroethan-1-ol; p-Bromo-α,α,α-trifluoromethylbenzyl alcohol; (4-Bromophenyl)(trifluoromethyl)carbinol
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Bromophenyl)-1,1,1-Trifluoropropan-2-Ol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.