Description

Boc-Dap(Fmoc)-Oh is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly in the construction of complex or sensitive sequences. It is primarily utilized in pharmaceutical R&D for the development of novel therapeutic peptides, peptide-based diagnostics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the Fmoc/t-Bu strategy, enabling the sequential addition of amino acids.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Combinatorial Chemistry: Serves as a valuable reagent in libraries for high-throughput screening of bioactive compounds.
• Bioconjugation: Facilitates the site-specific modification of peptides for creating antibody-drug conjugates (ADCs) or peptide-labeled probes.
• Academic & Institutional Research: Employed in biochemistry and molecular biology laboratories for studying protein structure and function.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Boc-Dap(Fmoc)-Oh
CAS No.	122235-70-5
Molecular Formula	C₂₄H₂₈N₂O₆
Molecular Weight	440.49 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-β-(9-fluorenylmethoxycarbonyl)-L-2,3-diaminopropionic Acid; Boc-Dap(Fmoc)-OH; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((tert-butoxycarbonyl)amino)propanoic Acid; N-α-Boc-N-β-Fmoc-L-2,3-diaminopropionic Acid; Boc-L-Dap(Fmoc)-OH; Fmoc-Dap(Boc)-OH; tert-Butyl N-[(2S)-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]-3-carboxypropyl]carbamate; L-2,3-Diaminopropionic Acid, N-α-Boc-N-β-Fmoc-
EINECS	Contact for details

Quality Control

Our Boc-Dap(Fmoc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP, ISO, and other relevant quality standards for pharmaceutical ingredient supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.