Description

Caspase-1 CAS NO 122191-40-6 is a crucial cysteine-aspartic acid protease enzyme, also known as Interleukin-1β Converting Enzyme (ICE), which plays a pivotal role in the inflammatory response and programmed cell death (pyroptosis). This enzyme is essential for the proteolytic activation of pro-inflammatory cytokines, making it a key target for research into inflammatory diseases and immune regulation. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on immunology, neurology, and oncology.

Application

• Biochemical Research: Used as a critical reagent for studying the mechanisms of inflammation, pyroptosis, and the innate immune system.
• Drug Discovery & Screening: Serves as a primary target for the development and high-throughput screening of novel anti-inflammatory therapeutics and caspase-1 inhibitors.
• In Vitro Diagnostic (IVD) Development: Employed in the development of assay kits and diagnostic tools for measuring caspase-1 activity in biological samples.
• Cell Biology Studies: Essential for experiments investigating cellular responses to pathogens, danger signals, and conditions that activate the inflammasome complex.
• Enzyme Characterization: Used in kinetic studies, substrate specificity profiling, and mechanistic enzymology research.
• Apoptosis & Pyroptosis Research: A key tool for differentiating between and studying various pathways of programmed cell death.

Basic Information

Product Name	Caspase-1
CAS No.	122191-40-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Interleukin-1β Converting Enzyme (ICE); IL-1β-Converting Enzyme; Caspase 1; CASP-1; p45; EC 3.4.22.36; ICE-like Protease; Protease, Interleukin 1β-Converting
EINECS	Contact for details

Quality Control

Our Caspase-1 is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high biological activity for research applications. Each lot undergoes rigorous analysis, including activity assays, purity assessment, and specificity testing. A comprehensive Certificate of Analysis (COA) detailing purity, specific activity, and storage buffer composition is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the lyophilized or solution form at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent moisture absorption, which can affect activity.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (Activity)	Conforms (Specific activity ≥ XX units/mg)
Purity (SDS-PAGE)	≥ 90%
Protein Content	Determined by UV absorbance or Bradford assay
Specific Activity	XX units/mg protein (measured by fluorometric assay)
Endotoxin Level	< 1.0 EU/μg (for cell culture applications)
Storage Buffer	Specified on COA (e.g., HEPES, DTT, Glycerol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.