Description

ω-Agatoxin I is a highly selective and potent peptide neurotoxin that irreversibly blocks P/Q-type voltage-gated calcium channels. This precise mechanism of action makes it an indispensable research tool for studying neuronal signaling, synaptic transmission, and channel physiology. It is primarily utilized by neuroscientists, pharmacologists, and biochemists in academic, pharmaceutical, and biotechnology research settings.

Application

• Neuroscience Research: A critical tool for investigating the role of P/Q-type calcium channels in neurotransmitter release, synaptic plasticity, and neuronal excitability.
• Pharmacological Studies: Used to characterize and validate the specificity of novel calcium channel modulators and drug candidates in vitro.
• Cellular Physiology: Employed to dissect calcium-dependent cellular processes, including hormone secretion and muscle contraction mechanisms.
• Channelopathy Research: Facilitates the study of diseases linked to calcium channel dysfunction, such as certain forms of migraine, ataxia, and epilepsy.
• Biochemical Assay Development: Serves as a reference standard in developing high-throughput screening assays for calcium channel activity.

Basic Information

Product Name	ω-Agatoxin I
CAS No.	121889-77-8
Molecular Formula	C185H274N52O55S7
Molecular Weight	~4170.8 g/mol
Synonyms	ω-Agatoxin I; ω-Aga-I; ω-Agatoxin IA; P/Q-type Calcium Channel Blocker; Agatoxin, ω-; Agatoxin I; FTX-3.3; Synthetic ω-Agatoxin I; Voltage-gated Calcium Channel Toxin
EINECS	Contact for details

Quality Control

Our ω-Agatoxin I is produced under stringent conditions to ensure the highest standards of purity and biological activity, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including mass spectrometry for sequence confirmation and HPLC for purity assessment. Certificates of Analysis (COA) detailing purity, potency, and endotoxin levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized powder at -20°C or below. Reconstituted solutions should be aliquoted to avoid repeated freeze-thaw cycles and stored at -80°C. The product is hygroscopic (moisture-sensitive); ensure the vial is equilibrated to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Potency (Biological Assay)	≥ 98%
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.