Description

3'-Iodo-4'-Azidosalicylamidoethylamido-7-Succinyldeacetylforskolin is a chemically modified derivative of forskolin, designed as a versatile photoaffinity labeling and crosslinking probe for biochemical research. This compound matters because it enables the covalent tagging and identification of forskolin-binding proteins and adenylate cyclase complexes, providing critical insights into cellular signaling pathways. Researchers in pharmaceutical discovery, molecular biology, and proteomics need this specialized reagent to study protein interactions, receptor mapping, and enzyme activation mechanisms with high specificity.

Application

• Photoaffinity Labeling: Covalent attachment to forskolin-binding sites on target proteins for identification and isolation.
• Adenylate Cyclase Research: Probing the structure, function, and regulation of adenylate cyclase enzymes and their complexes.
• Proteomics & Target Identification: Mapping protein-protein interactions and identifying novel binding partners in signaling cascades.
• Bioconjugation & Probe Development: Serving as a key intermediate for synthesizing advanced biochemical probes and affinity matrices.
• Cell Signaling Studies: Investigating cAMP-mediated pathways in cellular physiology and disease models.
• Drug Discovery: Used in hit validation and mechanism-of-action studies for compounds targeting G-protein-coupled receptor pathways.

Basic Information

Product Name	3'-Iodo-4'-Azidosalicylamidoethylamido-7-Succinyldeacetylforskolin
CAS No.	121878-20-4
Molecular Formula	C34H36IN7O9
Molecular Weight	853.59 g/mol
Synonyms	7-Deacetyl-7-succinyl-forskolin iodoazidosalicylamide; IASA-forskolin; 3'-Iodo-4'-azidosalicylamidoethylamido-7-succinyldeacetylforskolin; Forskolin photoaffinity label; cAMP activator photoaffinity probe; 7-O-Hemisuccinyl-7-deacetylforskolin 3'-iodo-4'-azidosalicylamide; IASA-FSK; Photoactivatable forskolin derivative
EINECS	Contact for details

Quality Control

Our 3'-Iodo-4'-Azidosalicylamidoethylamido-7-Succinyldeacetylforskolin is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to industry-standard analytical methods, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is both light-sensitive (store away from light) and hygroscopic (moisture-sensitive). For long-term stability, store under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.