Description

Interleukin-1Beta, Methionyl-Glutamyl-Alanyl-Glutamine- CAS NO 121797-27-1 is a synthetic peptide fragment derived from the interleukin-1β (IL-1β) cytokine, specifically designed for research and development applications. This compound is a critical tool for studying inflammatory pathways, immune system modulation, and cytokine-receptor interactions. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in immunology, drug discovery, and the development of novel therapeutic agents.

Application

• Immunological Research: Used as a reference standard or active component in studies of the IL-1 signaling pathway, inflammasome activation, and inflammatory disease models.
• Drug Discovery & Screening: Serves as a key reagent in high-throughput screening (HTS) assays to identify potential IL-1β inhibitors or modulators for autoimmune and inflammatory conditions.
• Biomarker Development: Employed in the development and calibration of immunoassays (e.g., ELISA) to detect and quantify IL-1β levels in biological samples.
• Cell Culture & Stimulation: Used to stimulate immune cells in vitro to study cytokine production, cell proliferation, and gene expression profiles.
• Receptor Binding Studies: Essential for investigating the binding affinity and kinetics of the IL-1β peptide fragment to its cognate receptor, IL-1R.
• Vaccine Adjuvant Research: Investigated for its potential role as an immunostimulant in next-generation vaccine formulations.

Basic Information

Product Name	Interleukin-1Beta, Methionyl-Glutamyl-Alanyl-Glutamine- CAS NO 121797-27-1
CAS No.	121797-27-1
Molecular Formula	C22H36N6O9S
Molecular Weight	560.62 g/mol
Synonyms	IL-1β (163-171); H-Met-Glu-Ala-Gln-OH; Methionyl-glutamyl-alanyl-glutamine; Interleukin 1 Beta Fragment 163-171; IL-1β Peptide (163-171); MEAQ Tetrapeptide; Immunostimulant Peptide; Acetyl-Met-Glu-Ala-Gln (Optional N-terminal modification)
EINECS	Contact for details

Quality Control

Our Interleukin-1Beta, Methionyl-Glutamyl-Alanyl-Glutamine is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to GMP principles for manufacturing and can provide material tailored to specific research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Biological Activity	Assay-dependent (e.g., Cell-based ELISA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.