Description

(R,R)-n-(1-Phenylethyl) Ibuprofen Amide is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it serves as a critical building block for the development of enantiomerically pure active pharmaceutical ingredients (APIs), where stereochemical control is paramount for efficacy and safety. It is primarily needed by research institutions and manufacturers in the pharmaceutical industry focused on chiral drug discovery, process chemistry, and the production of non-steroidal anti-inflammatory drugs (NSAIDs).

Application

• Chiral Resolution Agent: Used for the analytical and preparative separation of ibuprofen enantiomers.
• Pharmaceutical Intermediate: A key precursor in the synthesis of enantiomerically pure S-ibuprofen and related profen drugs.
• Asymmetric Synthesis Catalyst/ Ligand: Employed in the development of chiral catalysts or auxiliaries for stereoselective reactions.
• Reference Standard: Serves as a high-purity standard for quality control and method development in analytical laboratories (HPLC, GC).
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies and the design of novel anti-inflammatory agents.
• Process Development: Aids in optimizing and scaling up chiral synthesis routes within pilot plants and manufacturing facilities.

Basic Information

Product Name	(R,R)-n-(1-Phenylethyl) Ibuprofen Amide
CAS No.	121734-80-3
Molecular Formula	C21H27NO
Molecular Weight	309.45 g/mol
Synonyms	(R,R)-N-(1-Phenylethyl)-2-(4-isobutylphenyl)propanamide; (R,R)-N-(α-Methylbenzyl)ibuprofenamide; (R,R)-Ibuprofen (1-phenylethyl)amide; (R,R)-IBU-PEA; (2R)-N-[(1R)-1-Phenylethyl]-2-[4-(2-methylpropyl)phenyl]propanamide; (R,R)-Diastereomer of Ibuprofen Amide; Ibuprofen (R)-1-Phenylethylamide (R,R form)
EINECS	Contact for details

Quality Control

Our (R,R)-n-(1-Phenylethyl) Ibuprofen Amide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (R,R)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.