Description

(R)-(-)-Ibuprofen-D3 is a high-purity, deuterium-labeled stereoisomer of the widely used non-steroidal anti-inflammatory drug (NSAID) ibuprofen. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, providing unmatched accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D, clinical research, and forensic toxicology laboratories requiring precise measurement of ibuprofen and its metabolites in complex biological matrices.

Application

• Bioanalytical Internal Standard: Primary use as a stable isotope-labeled internal standard in LC-MS/MS and GC-MS methods for the quantification of ibuprofen in plasma, serum, and urine.
• Pharmacokinetic Studies: Enables accurate determination of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical trials.
• Metabolite Profiling: Aids in the identification and quantification of ibuprofen metabolites during drug metabolism and pharmacodynamics (DMPK) research.
• Forensic and Doping Control Analysis: Provides a reliable reference for confirming the presence and concentration of ibuprofen in forensic toxicology and anti-doping testing.
• Method Development and Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with FDA, EMA, and ICH guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Used in high-precision IDMS techniques to achieve superior accuracy and minimize matrix effects.

Basic Information

Item	Detail
Product Name	(R)-(-)-Ibuprofen-D3
CAS No.	121702-86-1
Molecular Formula	C13H15D3O2
Molecular Weight	209.30 g/mol
Synonyms	(R)-(-)-2-(4-Isobutylphenyl)propionic-3,3,3-d3 Acid; (R)-Ibuprofen-d3; Dexibuprofen-d3; (2R)-2-[4-(2-Methylpropyl)phenyl]propanoic-3,3,3-d3 Acid; (R)-α-Methyl-4-(2-methylpropyl)benzeneacetic-β,β,β-d3 Acid; (+)-(R)-Ibuprofen-d3; R-(-)-Ibuprofen-d3; Deuterated (R)-Ibuprofen
EINECS	Contact for details

Quality Control

Every batch of our (R)-(-)-Ibuprofen-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity suitable for sensitive mass spectrometry applications. Comprehensive testing includes assay, chiral purity, isotopic enrichment, and identification. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R-enantiomer)
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.