Description

3-Pyridylacetylene is a versatile heterocyclic alkyne building block essential for advanced organic synthesis. Its acetylene moiety attached to the pyridine ring makes it a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. This compound is primarily utilized by R&D chemists and process development scientists in the life sciences and specialty chemical industries for applications such as cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and neurological agents.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Serves as a monomer or linker in the synthesis of conductive polymers, metal-organic frameworks (MOFs), and advanced organic electronic materials.
• Cross-Coupling Reactions: An essential substrate for Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and coordination chemistry.
• Chemical Biology & Proteomics: Used as a bio-conjugation handle or probe in activity-based protein profiling and biomarker discovery.

Basic Information

Product Name	3-Pyridylacetylene
CAS No.	121697-66-3
Molecular Formula	C7H5N
Molecular Weight	103.12 g/mol
Synonyms	3-Ethynylpyridine; 3-Pyridylethyne; 3-Pyridinylacetylene; Pyridin-3-ylethyne; 1-(Pyridin-3-yl)ethyne; 3-(Ethynyl)pyridine; 3-Acetylenylpyridine
EINECS	Contact for details

Quality Control

Our 3-Pyridylacetylene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label. Due to its hygroscopic and easily oxidized nature, containers must be kept tightly sealed and allowed to reach room temperature before opening to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.